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Some medications used in the Hims Weight Loss plan, like compounded semaglutide, are not FDA-approved, which may raise concerns about their safety and efficacy

These long-term benefits are harder to achieve with GLP-1 medicines alone, as many patients stop using the medications over time. Study limitations and future research The authors highlighted that the study was observational, not a randomised controlled trial

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If retatrutide is more expensive or harder to source than tirzepatide for a given patient, stepping down to a similarly effective alternative makes sense