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He traced the effect to this small copper-binding peptide and launched five decades of research

In adults with obesity or overweight who have not achieved adequate results from lifestyle changes (like a reduced-calorie diet and increased physical activity) alone, the American Gastroenterological Association (AGA) recommends adding medication to the lifestyle changes rather than continuing with lifestyle modifications alone

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As documented by the FDA, practices such as taking a higher amount of the drug in a single dose, taking doses more frequently, or increasing the amount of the drug more quickly can cause serious gastrointestinal problems, including nausea, vomiting, diarrhea, and abdominal pain