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Zhu C, Lai Y, Liu C, Teng L, Zhu Y, Lin X, et al

Chronic low-grade inflammation is a common pathological feature of both: metabolic disturbances in patients with DM induce the release of peripheral inflammatory factors, and these inflammatory factors pass through the compromised BBB into the central nervous system (CNS), activating microglia and astrocytes and triggering a neuroinflammatory cascade response, which in turn promotes A deposition in AD and tau protein hyperphosphorylation (Sebastian Monasor et al., 2020

10.1038/s41416-021-01566-9 101 IshimotoT.NaganoO.YaeT.TamadaM.MotoharaT.OshimaH.et al (2011)

[Abstract] Biomater Res