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KEY TAKEAWAYS Restricting calories on GLP-1 medications can lower your metabolic rate and weaken your body's natural GLP-1 production Liposuction during skin removal surgery may disrupt leptin signaling, though males may be less affected than females due to naturally lower leptin levels Finding metabolic-informed doctors globally remains challenging, but obesity medicine certification and Canadian and European obesity organizations may offer better resources The oral GLP-1 medication orforglipron will likely be less expensive but also less effective than dual-agonist medications like tirzepatide Mechanical eating without calorie counting often produces better long-term results than restrictive approaches Vegetables provide essential micronutrients and support healthy microbiome function that protein alone cannot replace Major weight loss surgery like tummy tucks is serious surgery that requires careful consideration and qualified surgeons NOTE: This episode was recorded before Foundayo (orforglipron) was released on the market

Glutathione Levels Increased Across All Blood Samples Liposomal Glutathione raised glutathione levels in all parts of the blood tested: Whole Blood: 40% after 2 weeks Erythrocyte (red blood cells): 28% after 1 and 2 weeks Plasma (liquid part of blood that carries nutrients, hormones, and waste but no cells): 25% after 2 weeks PBMC (white blood cells): 100% after 2 weeks Increases occurred in all compartments suggesting a systemic effect and that other less-accessible tissues may be impacted in a similar manner. Participants starting with lower glutathione (GSH) levels saw the biggest improvements after taking the supplement

PubMed Aronne LJ, et al