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These include pathways related to DNA repair, antioxidant defense, and tissue regeneration, as well as reduced expression of genes associated with inflammation and matrix degradation

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Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

Reduced NAD+ availability is associated with impaired cellular energy production, elevated oxidative stress, and accelerated markers of biological aging in animal models