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While more human clinical trials are needed, anecdotal reports and real-world results are encouraging

The side effects also are minimal, but you should consult your healthcare provider before adding it to any other medication or supplements youre already taking

The regulatory effect of metformin on the microbiota extends beyond GSH to include microbial metabolites such as short-chain fatty acids (SCFAs), which have been shown to inhibit tumor proliferation and protect against intestinal injury [34,35,36]

There are many agents with a well known depigmenting effect like pycnogenol, orchid extract, marine algae extract, cinnamic acid, soy, aloesin, Boswellia , hydroquinone, glycolic acid, arbutin, kojic acid, ascorbate, tocopherol, niacinamide, etc