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This potent antioxidant acts as the defense line to fight against free radicals and other DNA-affecting compounds present in pollutants, overexposure to sun rays, and smoking habits

Study limitations include presence of statistical heterogeneity in the meta-analyses for change in HbA 1c and body weight, assessment of risk of bias solely for the primary outcome, and generalisation of findings mainly to individuals who are overweight or obese and already on metformin-based background therapy

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These early improvements reflect the pineal gland and melatonin normalization effect