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An early study 25 addressed this question by genotyping 9 SNPs associated with serum UA in a series of PD and matched control subjects to obtain a polygenic risk score (PRS) for low UA

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Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized, doubleblind, parallelcontrolled clinical trial

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