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PCAC member Elizabeth Rebello, a professor in the Department of Anesthesiology and Perioperative Medicine at the University of Texas MD Anderson Cancer Center, noted the "lack of efficacy data and randomized controlled trials" for these compounds

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However, many endogenous and exogenous factors such as free radicals produced by chronic inflammation in the body, certain metabolites of cells and gut microbiota [14], as well as chemical carcinogens in the environment [15], ultraviolet (UV) radiation attack intracellular DNA and may cause a variety of DNA damage [3]