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These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability

After the exclusion of 328 duplicates, the remaining 979 abstracts were assessed for inclusion in the meta-analysis

Rouhimoghadam M, Safarian S, Carroll JS, Sheibani N, Bidkhori G

In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop