Excessive free radicals can damage cellular components such as lipids, proteins, and DNA, contributing to chronic conditions like cardiovascular diseases, neurodegenerative disorders, cancer, and inflammatory diseases [8, 21]
In addition, albumin has an average plasma half-life of three weeks in humans 1,5 , a feature that is increasingly exploited to improve the pharmacokinetic (PK) properties of short-lived biologics, including peptide hormones, cytokines, coagulation factors, and antibody fragments 6,7,8,9,10,11,12,13,14,15
This potential pathogenic association opens the window for their use as potential non-invasive biomarkers of MASLD, as well as for potential therapeutic targets, which are also discussed hereby
Most people with type 1 diabetes will use an intermediate- or long-acting insulin for half of their daily dose