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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

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Felson, MD, MPH, of Boston University School of Medicine, wrote that "the findings confirm that substantial weight loss causes an often dramatic reduction in pain." Obesity "markedly increases" the risk of knee osteoarthritis, he said