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Yes, as your body weight decreases, your basal metabolic rate and total calorie requirements naturally reduce, so calorie intake should be periodically reassessed with your healthcare provider to ensure continued safe and effective weight management

one patient had an initial improvement in both glycemia and weight followed by weight regain and deterioration of glycaemic control, and one patient experienced only glycemia improvement with weight gain (42)

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Research suggests that oral doses of up to 500 mg daily may be safe for short-term use (up to two months) without significant side effects