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Timothy Gill, a professor of public health nutrition at the University of Sydney, expressed ambivalence about semaglutide

Lower-dose treatment might one day suit certain patients, but she said, "Researchers need strong clinical trials first." She outlined what would have to come together: studies testing lower doses directly rather than in theory, proof that the results hold up over years without significant weight re-gain, a clearer picture of who benefits most, consistent manufacturing standards, and regulatory review of the evidence

In 2017, under pressure to move more quickly, the FDA came up with an interim solution