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RLM incubation in combination with a NADPH regenerating system and 3A4 Supersomes in the presence of NADPH yielded optimal conditions for APAP in vitro metabolism

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The role of CHAC1 in apoptosis is highlighted by its function as a pro-apoptotic factor that can deplete intracellular GSH levels, reducing the cells ability to counteract ROS and oxidative stress, thereby promoting apoptotic cell death