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A randomized clinical trial published in JAMA Psychiatry demonstrated reduced alcohol craving and consumption among participants receiving semaglutide, with secondary reductions in cigarette use among smokers (Hendershot et al., 2024)

Now that weve covered the basic idea, lets look at what each medication is actually doing and why those differences matter

Jordan Peterson, Ph.D., psychologist, professor emeritus at the University of Toronto, best-selling author, and prominent online educator

Many plateaus happen because your body has changed: Less muscle mass Lower calorie needs Reduced protein intake Poor sleep or higher stress Less activity Tirzepatide generally produces greater average weight loss than semaglutide, so switching isnt always the solution