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While the body does produce natural GLP-1, this endogenous hormone is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes of secretion, making it unsuitable as a therapeutic agent without pharmaceutical modification

Calculation of Drug Impact Effect Scores within the DM2-AD comorbidity network for metformin combination therapies We also investigated which metformin combination therapies exhibit the highest impact scores in preventing AD in DM2

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Shares of the company climbed more than 200% last year, and the stock is already up more than 100% this year despite Friday's move