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The second site is called Multi-Metal Binding Site (MBS), responsible mainly for binding of Zn(II) ions 23

Neurobiol Dis 10:268278 Van Den Bosch L, Tillkin P, Lemmens G et al (2002) Minocycline delays disease onset and mortality in a transgenic model of ALS

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Moreover, there are studies indicating that experimental treatments which reduce the concentration of IGF-1 in plasma, e.g., caloric restriction, are able to extend the lifespan of several animal species