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Tesamorelin is a GHRH analogue designed to stimulate pituitary GHRH receptors to increase endogenous growth hormone (GH) and insulin-like growth factor-1 (IGF-1) secretion
Several studies have suggested modulating this signaling cascade through miRNAs and natural compounds such as curcumin
This is thanks to growing clinical evidence
The vascular endothelium modulates muscle perfusion through NOmediated vasodilation, whereas skeletal muscle subsequently secretes myokines such as interleukin-6 (IL-6), irisin, and vascular endothelial growth factor (VEGF), which influence endothelial cell activity, angiogenesis, and vascular remodeling (16, 17)
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