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Participants were 70% female and included those who were obese and had a high rate of prior exposure to advanced therapies, representing a difficult to treat population, according to the researchers

2013 Apr 11;368(15):1425-33 Acute rheumatic fever (ARF) is an inflammation of the heart, skin, joints and/or brain which develops after infection with Group A streptococci, such as "strep" throat, or scarlet fever