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In a zebrafish model, compared with C3-carnitine, C18-carnitine and C18:1-carnitine can induce the inhibition of OXPHOS, interfere with the energy supply of cardiomyocytes, and lead to a significant impairment of cardiac systolic function, which manifests as a decreased heart rate and reduced shortening of the atrial and ventricular fractions [21]

[DOI] [PubMed] [Google Scholar] 521.Hay C.W., Sinclair E.M., Bermano G., Durward E., Tadayyon M., Docherty K

The increase from 10 mg to 15 mg yields more modest incremental benefit

4d, e), in agreement with recent reports which also indicate SPHKAP localisation and PKA-RI targeting to the ER 32,33