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The medication should be initiated at a 2.5 mg dose and, if necessary, gradually increased to the recommended maintenance dosages of 5 mg, 10 mg, or 15 mg based on the patients response and tolerance

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By lowering oxidative stress levels, SEM can help mitigate the damage caused by excessive Ca 2+ influx and reactive oxygen species (ROS) generation [40]

PMID: 65 LiaoPWangWWangWKryczekILiXBianYet al