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Clinical Presentation Acute overdosage with hydrocodone bitartrate and acetaminophen tablets can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, hypoglycemia, partial or complete airway obstruction, atypical snoring, and death

Pro-inflammatory cytokines disrupt neurotransmitter metabolism through mechanisms such as inhibited tryptophan conversion to serotonin while driving microglial activation, thereby amplifying neuroinflammation (271)

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