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CSF contains very low metabolite concentrations but contributes to the water signal from the region of interest, so it is necessary to correct the metabolite for this apparent dilution effect

Patients with cardiovascular (CV) risk, for instance, FDCs planned with sitagliptin and metformin or empagliflozin have shown superiority versus monotherapy on the grounds of treatment efficacy in clinical trials [29]

This receptor-level specificity differentiates PT-141 from hormonal therapies that broadly alter endocrine balance

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