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Additional distinguishing features include the presence of dense pigmentation, lack of maturation, nuclear pleomorphism, mitotic activity, apoptosis, lymphocytic infiltration, and a deep nested growth pattern, which are commonly evident in melanoma but not in intradermal nevi

Also, both systolic and diastolic dysfunction stemming from the interplay between atherosclerotic coronary disease and diabetic cardiomyopathy are associated with the underlying pathophysiology of HF in patients with T2DM [45, 46]

Moreover, co-encapsulation of synbiotics and L-carnitine as a single micro-capsule could be considered as a conceivable delivery system to enhance the stability and efficacy of synbiotics, as well as to reduce the cost of the final product

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