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The first approach involved treating the cells with increasing tamoxifen concentrations starting with 100 nM until a concentration of 50 M was reached

These bumps are keratin plugs (created from defective shedding of corneocytes) [1] that form within the follicular canal, with or without a hair follicle being present in the follicular canal

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Further, the incorporation of glutathione led to an increase in the expression of antioxidant enzymes, such as SOD and catalase, by activating the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway