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In the context of lipid metabolism, targeting pathways such as ether lipid synthesis, fatty acid synthase (FASN), or the ACLY/ACC axis has been shown to induce mitochondrial stress and ROS accumulation, thereby enhancing apoptotic responses [144]

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Measurement of iron concentration The intracellular iron concentration was quantified using a Total Iron Content Colorimetric Assay Kit (Applygen #E1042, Beijing, China) according to the manufacturers instructions