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Additionally, lipoic acid increased mitochondrial biogenesis through triggering AMP-activated protein kinase (AMPK)-induced transcription factor PGC-1 activation in skeletal muscle of aged mice (48)

Furthermore, the activation of intracellular pathways, such as PI3K/Akt and cAMP/PKA by GLP-1RA contributes to decreased oxidative stress, inhibition of neuronal apoptosis, and improved mitochondrial function

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