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Age-related reduction of mitochondrial function is accompanied by a decline in the mitochondrial capacity for ATP production by oxidative phosphorylation [62], a reduction in the NAD + pool [63] by consuming processes (PARP, CD38, and SIRT1) [64], and further an increase in ROS generation by an inefficient electron transport chain (ETC) [26]

If signs of OH are found, the treatment plan may need to be adjusted

It may last from 30 minutes to a few hours

Conversely, research focused on the enzymatic activity of copper-dependent enzymes like lysyl oxidase would necessitate the use of the GHK-Cu complex to ensure copper bioavailability