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Bose P, Pemmaraju N, Masarova L, Bledsoe SD, Daver NG, Jabbour EJ, Kadia TM, Estrov Z, Kornblau SM, Andreeff M , Cortes JE, Jain N, Borthakur G, Alvarado Y, Huynh-Le J, Henriquez M, Richie MA, Dobbins M, Zhou L, Pierce SA, Wang X, Pike AM, Garcia-Manero G, Kantarjian HM, Verstovsek S

2015;10:e0139985

This effect tends to be dose-dependent and often diminishes as exposure stabilizes

Conclusion The rationally designed nanocomplex provides a ROS drug enhancement and targeted delivery platform, representing a potential solution by disrupting redox balance for AML therapy