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This suggests that patients gradually adapt to the medication when they start the treatment, resulting in a lower incidence and severity of adverse events

Ipamorelin is unique among growth hormone releasing peptides in that, unlike most, it does not activate the bodys natural stress response

Furthermore, it has been shown that physiological high estradiol levels correlate with increased leptin sensitivity and that reduced leptin sensitivity after oophorectomy can be restored with estrogen treatment (154)