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As more long-term outcomes data become available, particularly from the SURPASS-CVOT trial, these models will be further refined

These results indicate that in ASD patients, a preponderance of mitochondrial fission is coupled to impaired mitophagy [79]

Both GLP-1 drugs and bariatric surgery are known to improve blood sugar control, which is why semaglutide was originally approved as a treatment for type 2 diabetes

This treatment effectively reduced astrogliosis, dystrophic microglia, and promoted neurogenesis, demonstrating a potent neuroprotective effect on early DS phenotypic deficits and dementia (Capsoni and Cattaneo 2022)