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Importantly, obesity and diabetes are associated with impairments in gutbrain signaling 68,311 , and the success of both surgical and pharmacological treatments for both diseases is due at least in part to alterations in the gutbrain axis 6,7,10,131

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doi: 10.7759/cureus.6170

Given these observations, the depletion of A is expected to slow down or, hopefully, even prevent the cognitive decline associated with AD in affected individuals