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Increased activity of NADPH oxidase reduces the concentration of free NADPH that is needed to reduce GSSG to GSH

Under normal conditions, there is a well-regulated equilibrium in the GI mucosa between inflammatory cytokines (such as TNF-, IL-1, IL-6, IL-8, IL-17, and IL-23) and anti-inflammatory cytokines (like IL-5, IL-10, IL-11, and TGF-) (75)

The provided clinical studies do not specifically address post-inflammatory hyperpigmentation of the tongue

But I couldnt find any information in the clinical-trial reports or FDA fact sheets about sulfur burps in particular, and neither Novo Nordisk nor Eli Lilly, the companies that make these drugs, responded to my inquiries