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A 48-week Phase 2 trial reported in The Lancet in 2025 showed mean weight reduction ranging from approximately 9% at the lowest dose to 20% at the highest dose, compared with 0.4% on placebo

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Despite these observations, larger observational studies and population-based analyses have not consistently demonstrated a remarkable increase in clinically meaningful postoperative aspiration pneumonia among patients receiving GLP-1 receptor agonists