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J Toxicol Environ Health 1998: 55: 1329 Lu FC

2.4 Statistical analysis 2.4.1 MR analysis Before MR analysis, we harmonized exposure and outcome data by aligning effect alleles to the forward strand, discarding palindromic variants

GLP-1 agonists also reduced headache risk, with the most significant effect at 3 months (RR: 0.69), remaining statistically significant at 6, 12, and 24 months