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These studies showed significant alterations in ceramide levels as well as benzoate, creatine and fatty acid metabolisms and sphingomyelins pathways, with respect to ALS progression 49 , and these changes in metabolite levels correlated with patients ALS Functional Rating Scale (ALSFRS-R) scores 55

3.1 Mechanistic insights of degradation of PAH pollutants PAHs constitute a significant class of environmental pollutants, with notable examples including naphthalene, anthracene, phenanthrene, pyrene, and benzo [a]pyrene

Eur J Biochem 47:469474 Mohammad MK, Avila D, Zhang J et al (2012) Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress

Diabetologia 61 , 413423 (2018)