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The AGEs modify soluble neurofilament proteins into insoluble aggregates, a process which occurs when RAGE binds to A peptides, thereby inducing the release of ROS and, as a consequence, favoring the oligomerization of these peptides

1.9 Hashimotos thyroiditis and genetic predisposition Although the cause of HT is multifactorial, it has been demonstrated that HT is linked to genetic alterations and HLA status in addition to surrounding impacts such as iodine procuration, infections, and stress

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