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While these two both contain semaglutide, they are approved for different uses

Yet we have seen scores of patients diagnosed with FMS who never had even a simple blood test taken to rule out anemia or hypothyroidism, which are 2 common conditions that result in symptoms of fatigue and muscle aches, respectively

Novo Nordisk has also cited indirect comparison data suggesting that fewer patients discontinued oral semaglutide due to side effects compared with orforglipron, though the companies and independent commentators note the significant methodological limitations of such comparisons in the absence of a head-to-head obesity trial

An important note on folate: if B12 deficiency is suspected, folate deficiency should not be corrected in isolation before B12 status has been assessed and treated, as doing so can precipitate or worsen neurological complications