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What Both Medications Do Inside the Body Although the delivery systems differ, both medications activate the GLP-1 receptor and trigger similar downstream effects: Increased insulin release in response to elevated blood sugar Reduced glucagon secretion Slower gastric emptying Reduced appetite signaling Increased satiety after meals According to the National Institute of Diabetes and Digestive and Kidney Diseases, these mechanisms can support improved blood sugar regulation and meaningful weight reduction when combined with lifestyle interventions

It is crucial to ensure that all diagnostic codes are from the current ICD-10-CM classification system

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I dont usually prescribe them together off the bat, but I do have patients come to me on metformin and will add a GLP-1 medication such as Wegovy, says Tzvi Doron, DO, DABFM, DABOM, a board-certified obesity and family medicine specialist in New York