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Supplementation of the diet with lysine can restore carnitine levels, however, there appeared to be impairment of carnitine biosynthesis in ethanol-compromised livers in the rat study [71]

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Later on, it has been shown that more than 200 variants exist in the coding region of TMAO producing enzyme, with different outcomes on the cardiovascular risk (Phillips and Shephard, 2020)

Similarly, TMAO induces M1 polarization of bone marrow-derived macrophages by nucleotide binding to oligomerization domain-like receptor protein 3 (NLRP3), which aggravates acute graft vs