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Allegations against Novo Nordisk include that Wegovy (generic name semaglutide) causes gastrointestinal issues, vision loss (NAION), and now blood clot-related side effects, which the company does not properly warn patients about
The evidence base for DSIP in humans is limited
353 These findings confirm that in the synovium, GLP-1R is expressed on two different cell types, macrophages and fibroblast-like synoviocytes, which are specialized cells distributed within the synovial intima and subintima, and these cell types play important roles in hyaluronic acid synthesis, metabolite processing, and clearance of matrix degradation fragments
Although the detailed mechanism is poorly understood, BPC 157 appears to be beneficial to almost all organ systems in many species when very low dosages (mostly ng/kg to g/kg range) after ip, ig, and intramucosal (local) application are used and no side effect or toxicity is found
