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After an initial loading phase of six injections over two weeks (or more frequently if neurological symptoms are present), maintenance injections are given every two to three months for life to prevent deficiency recurrence

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Other reported mechanisms include activation of FAK-paxillin complexes (which help cells migrate and attach to surfaces during wound healing), JAK-2 signaling, and ERK1/2 pathway activity (Sikiric et al., Current Neuropharmacology, 2016

In lung cancer patients with carcinomatous pleurisy, the levels of IL-6 and IL-8 are higher, and the soluble form of sIL-6R is lower in effusion fluid compared to normal individuals [114]