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The mITT population included all randomised participants who took at least one dose of study drug

Among the most important are the degeneration of dopaminergic neurons and the loss of the substantia nigra, combined with the intracellular aggregation of -synuclein, which forms Lewy bodies and neurites [7]

Keep all follow-up visits To minimize potential adverse effects of spironolactone, your healthcare provider may require follow-up visits and tests to monitor blood pressure, electrolytes, blood volume, kidney function, and liver function so they can spot issues before they become serious problems