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I think a lot of companies were going to see maybe shifting away from this custom approach because they are afraid that the FDA could come in any day and shut them down and say you cant do this anymore. George Ball, Indiana University associate professor of operations and decision technologies, has a different take on the situation

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Physical symptoms of anxiety include persistent restlessness or feeling on edge, increased heart rate or palpitations, rapid breathing or shortness of breath, excessive sweating, trembling or shaking, muscle tension particularly in the neck and shoulders, gastrointestinal disturbances such as nausea or diarrhea, and sleep disturbances including difficulty falling or staying asleep

doi: 10.1111/j.1463-1326.2008.00860.x