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In some trials, up to 45 percent of patients experienced nausea

Effect of curcumin supplementation during radiotherapy on oxidative status of patients with prostate cancer: a double blinded, randomized, placebo-controlled study

CSD is associated with significant cerebral vasoconstriction (13), which triggers neuronal swelling and activation of meningeal trigeminal nerve endings and the trigeminal vascular system, ultimately contributing to migraine development (1416)