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10.1007/112_2006_0702 133 KappelerR.EichholzerM.RohrmannS

FrixenUHBehrensJSachsMEberleGVossBWardaAet al

To explore ferroptosis-related mechanisms, the AddModuleScore function was used in combination with a ferroptosis gene set to calculate a ferroptosis score for each cell

Key regulatory axesincluding HIF-1, HHIP-PKM2, PTGES-AKT-HIF-1, and lactate/LDH-A (LDH5)-TGF-interact to collectively promote enhanced glycolysis and diminished oxidative metabolism, sustaining the pathological phenotype of the disease ( Abnormalities in the PPP are primarily manifested as oxidative stress-induced compensatory activation