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When ghrein was administered first, its plasma concentration also reached the peak at 5 min and returned to the base at 30 min when GLP-1 was administered (Supplementary Fig

Similar prophylactic results were obtained with 5-aminosalicylic acid treatments when conjugated to bile acids or aryl aldehydes in order to prevent the absorption of 5-aminosalicylic acid in the small intestine, allowing it to be released in the caecum/large intestine, improving its pharmacological profile (Goto et al