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H 2 selectively reacts with hydroxyl radicals in living cells Oxidative stress is derived by excessive generation of reactive oxygen species (ROS) such as superoxide anion radical (O 2 -), hydrogen peroxide (H 2 O 2 ), nitric oxide (NO), and hydroxyl radical (OH) [9-10]

This enzyme is localized into mitochondria and acts in two crucial pathways of the energetic metabolism, such as the Krebs cycle and the electron transport chain, by converting succinate into fumarate, together with the reduction of flavin adenine dinucleotide (FAD) into FADH 2

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