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Starting metformin at a low dose (500 mg once or twice daily) and gradually increasing over several weeks allows for more gradual glucose reduction, potentially minimizing the magnitude of osmotic lens changes

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5 Paxillin, a focal adhesion scaffolding protein that binds directly to FAK and mediates cytoskeletal remodeling, is phosphorylated in BPC-157-treated endothelial cells in a pattern consistent with enhanced migratory phenotype precisely the phenotype required for endothelial cells to form new capillary tubes during angiogenesis